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cellular · supported

Nrf2 Activation

Nrf2 is the master regulator of antioxidant enzymes (SOD, catalase, HO-1).

Evidence note: Curcumin, sulforaphane, and other phytochemicals activate Nrf2 in human studies.

EVIDENCE

supported

INGREDIENTS

BIOMARKERS

What it
changes.

Activating this pathway affects the following measurable biomarkers.

↓

C-Reactive Protein

mg/L

<1.0 mg/L (low CV risk)

What
affects it.

amino-acid

N-Acetylcysteine

Glutathione precursor. Antioxidant and mucolytic.

established$

polyphenol

EGCG (Green Tea Catechin)

Main catechin in green tea. Inhibits COMT, amplifies thermogenesis with caffeine.

established$

antioxidant

Alpha-Lipoic Acid

Universal antioxidant. R-ALA is the biologically active form.

supported$$

mushroom

Reishi (Ganoderma lucidum)

Adaptogenic mushroom. Studied for immune function and stress.

supported$$

mushroom

Chaga (Inonotus obliquus)

High in melanin and antioxidants. Studied for immune support.

emerging$$

adaptogen

Schisandra Chinensis

Adaptogen studied for liver protection and stress resilience.

supported$$

fatty-acid

Omega-3 (EPA/DHA)

EPA and DHA. Anti-inflammatory. Supports brain and cardiovascular health.

established$$

vitamin

Vitamin C

Required for collagen synthesis. Regenerates vitamin E.

established$

mineral

Selenium

Cofactor for glutathione peroxidase. Antioxidant defense.

established$

antioxidant

CoQ10 (Ubiquinone / Ubiquinol)

Electron carrier in mitochondrial ATP production. Ubiquinol is the reduced, active form.

supported$$

polyphenol

Curcumin

Anti-inflammatory polyphenol. Poor bioavailability unless enhanced with piperine or phospholipids.

supported$$

polyphenol

Resveratrol

Studied for longevity pathways. Human data is mixed.

emerging$$$

polyphenol

Sulforaphane

Potent Nrf2 activator. Requires myrosinase for conversion.

supported$$

botanical

Piperine (Black Pepper Extract)

Increases bioavailability of curcumin and other compounds by inhibiting glucuronidation.

established$

antioxidant

Astaxanthin

Carotenoid antioxidant. Studied for skin, eyes, and exercise recovery.

supported$$

Nrf2 Activation

What it changes.

What affects it.

Contributes to these goals.

What it
changes.

What
affects it.