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GOAL · 🧬

Brain Health (long-term)

Long-term neurological protection — neuroinflammation, oxidative stress.

PATHWAYS
3
BIOMARKERS
4
INGREDIENTS
19

How you
get there.

These biological pathways drive progress toward brain health (long-term).

supported
Nrf2
Nrf2 Activation

Nrf2 is the master regulator of antioxidant enzymes (SOD, catalase, HO-1).

supported
NF-κB
NF-κB Inhibition

NF-κB is a master inflammatory switch. Inhibiting it reduces chronic inflammation.

supported
Mito Biogenesis
Mitochondrial Biogenesis

Creating new mitochondria. Increases cellular energy capacity.

What to
measure.

Track these biomarkers to see if your progress is real.

↓
C-Reactive Protein
mg/L
<1.0 mg/L (low CV risk)
↓
Interleukin-6
pg/mL
<5 pg/mL
↓
TNF-α
pg/mL
<8.1 pg/mL
↑
VO2max
mL/kg/min
35–55 mL/kg/min (trained adults)

What
helps.

amino-acid
Acetyl-L-Carnitine

Carnitine form that crosses the blood-brain barrier. Studied for cognition and neuropathy.

supported$$
amino-acid
N-Acetylcysteine

Glutathione precursor. Antioxidant and mucolytic.

established$
polyphenol
EGCG (Green Tea Catechin)

Main catechin in green tea. Inhibits COMT, amplifies thermogenesis with caffeine.

established$
botanical
Shilajit (PrimaVie)

Fulvic acid mineral complex. Possibly effective for testosterone in hypogonadal men [citation:31].

supported$$$
antioxidant
Alpha-Lipoic Acid

Universal antioxidant. R-ALA is the biologically active form.

supported$$
mushroom
Cordyceps

Studied for exercise performance and oxygen utilization. Human data mixed.

supported$$
mushroom
Lion's Mane (Hericium erinaceus)

Stimulates NGF synthesis. Studied for cognition and nerve regeneration.

supported$$
mushroom
Reishi (Ganoderma lucidum)

Adaptogenic mushroom. Studied for immune function and stress.

supported$$
mushroom
Chaga (Inonotus obliquus)

High in melanin and antioxidants. Studied for immune support.

emerging$$
adaptogen
Schisandra Chinensis

Adaptogen studied for liver protection and stress resilience.

supported$$
fatty-acid
Omega-3 (EPA/DHA)

EPA and DHA. Anti-inflammatory. Supports brain and cardiovascular health.

established$$
vitamin
Vitamin C

Required for collagen synthesis. Regenerates vitamin E.

established$
mineral
Selenium

Cofactor for glutathione peroxidase. Antioxidant defense.

established$
antioxidant
CoQ10 (Ubiquinone / Ubiquinol)

Electron carrier in mitochondrial ATP production. Ubiquinol is the reduced, active form.

supported$$
polyphenol
Curcumin

Anti-inflammatory polyphenol. Poor bioavailability unless enhanced with piperine or phospholipids.

supported$$
polyphenol
Resveratrol

Studied for longevity pathways. Human data is mixed.

emerging$$$
polyphenol
Sulforaphane

Potent Nrf2 activator. Requires myrosinase for conversion.

supported$$
botanical
Piperine (Black Pepper Extract)

Increases bioavailability of curcumin and other compounds by inhibiting glucuronidation.

established$
antioxidant
Astaxanthin

Carotenoid antioxidant. Studied for skin, eyes, and exercise recovery.

supported$$