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GOAL · ⏳

Longevity

Healthspan extension — slower aging, better biomarkers, resilience.

PATHWAYS
5
BIOMARKERS
4
INGREDIENTS
19

How you
get there.

These biological pathways drive progress toward longevity.

supported
Nrf2
Nrf2 Activation

Nrf2 is the master regulator of antioxidant enzymes (SOD, catalase, HO-1).

emerging
Autophagy
Autophagy

Autophagy is cellular cleanup — removing damaged components.

emerging
Sirtuins
Sirtuin Activation

Sirtuins are longevity-associated proteins involved in DNA repair and metabolism.

supported
Mito Biogenesis
Mitochondrial Biogenesis

Creating new mitochondria. Increases cellular energy capacity.

supported
NF-κB
NF-κB Inhibition

NF-κB is a master inflammatory switch. Inhibiting it reduces chronic inflammation.

What to
measure.

Track these biomarkers to see if your progress is real.

↓
C-Reactive Protein
mg/L
<1.0 mg/L (low CV risk)
↓
Interleukin-6
pg/mL
<5 pg/mL
↑
VO2max
mL/kg/min
35–55 mL/kg/min (trained adults)
↓
TNF-α
pg/mL
<8.1 pg/mL

What
helps.

amino-acid
Acetyl-L-Carnitine

Carnitine form that crosses the blood-brain barrier. Studied for cognition and neuropathy.

supported$$
amino-acid
N-Acetylcysteine

Glutathione precursor. Antioxidant and mucolytic.

established$
polyphenol
EGCG (Green Tea Catechin)

Main catechin in green tea. Inhibits COMT, amplifies thermogenesis with caffeine.

established$
botanical
Shilajit (PrimaVie)

Fulvic acid mineral complex. Possibly effective for testosterone in hypogonadal men [citation:31].

supported$$$
antioxidant
Alpha-Lipoic Acid

Universal antioxidant. R-ALA is the biologically active form.

supported$$
mushroom
Cordyceps

Studied for exercise performance and oxygen utilization. Human data mixed.

supported$$
mushroom
Lion's Mane (Hericium erinaceus)

Stimulates NGF synthesis. Studied for cognition and nerve regeneration.

supported$$
mushroom
Reishi (Ganoderma lucidum)

Adaptogenic mushroom. Studied for immune function and stress.

supported$$
mushroom
Chaga (Inonotus obliquus)

High in melanin and antioxidants. Studied for immune support.

emerging$$
adaptogen
Schisandra Chinensis

Adaptogen studied for liver protection and stress resilience.

supported$$
fatty-acid
Omega-3 (EPA/DHA)

EPA and DHA. Anti-inflammatory. Supports brain and cardiovascular health.

established$$
vitamin
Vitamin C

Required for collagen synthesis. Regenerates vitamin E.

established$
mineral
Selenium

Cofactor for glutathione peroxidase. Antioxidant defense.

established$
antioxidant
CoQ10 (Ubiquinone / Ubiquinol)

Electron carrier in mitochondrial ATP production. Ubiquinol is the reduced, active form.

supported$$
polyphenol
Curcumin

Anti-inflammatory polyphenol. Poor bioavailability unless enhanced with piperine or phospholipids.

supported$$
polyphenol
Resveratrol

Studied for longevity pathways. Human data is mixed.

emerging$$$
polyphenol
Sulforaphane

Potent Nrf2 activator. Requires myrosinase for conversion.

supported$$
botanical
Piperine (Black Pepper Extract)

Increases bioavailability of curcumin and other compounds by inhibiting glucuronidation.

established$
antioxidant
Astaxanthin

Carotenoid antioxidant. Studied for skin, eyes, and exercise recovery.

supported$$