HOME/MECHANISMS/COMT
neurotransmitter · supported

COMT Inhibition

COMT breaks down norepinephrine. Inhibiting it prolongs sympathetic activation.

Evidence note: EGCG inhibits COMT in vitro. The EGCG + caffeine combination increases thermogenesis in humans.
EVIDENCE
supported
INGREDIENTS
1

What
affects it.

polyphenol
EGCG (Green Tea Catechin)

Main catechin in green tea. Inhibits COMT, amplifies thermogenesis with caffeine.

established$

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