HOME/BIOMARKERS/HOMA-IR
metabolic · index

HOMA-IR

Calculated index of insulin resistance from fasting glucose and insulin.

DIRECTION
↓ lower is better
NORMAL RANGE
<2.0
MECHANISMS
2

What
moves it.

These biological pathways influence HOMA-IR. Click any to see what affects it.

established
AMPK
AMPK Activation

AMPK is the cell's energy sensor. When activated, it mimics caloric restriction — boosting fat oxidation and glucose uptake.

established
Insulin
Insulin Sensitivity

Insulin sensitivity determines how efficiently cells absorb glucose.

What
affects it.

botanical
Fenugreek

Contains 4-hydroxyisoleucine, which stimulates insulin release. Studied for testosterone and creatine uptake.

supported$$
botanical
Berberine

Activates AMPK. Reduces blood glucose and HbA1c in human RCTs.

established$$
mineral
Chromium

Enhances insulin signaling. Modest effects on weight and blood sugar.

supported$
antioxidant
Alpha-Lipoic Acid

Universal antioxidant. R-ALA is the biologically active form.

supported$$
botanical
Cinnamon (Ceylon)

May improve insulin sensitivity and blood glucose. Ceylon variety is safer for long-term use.

supported$
botanical
Gymnema Sylvestre

May reduce sugar absorption and improve insulin sensitivity.

supported$