HOME/MECHANISMS/NO
vascular · established

Nitric Oxide Production

NO dilates blood vessels, improving blood flow to muscles and brain.

Evidence note: Citrulline raises blood arginine and NO more efficiently than arginine itself [citation:9].
EVIDENCE
established
INGREDIENTS
4
BIOMARKERS
2

What it
changes.

Activating this pathway affects the following measurable biomarkers.

↓
Systolic Blood Pressure
mmHg
<120 mmHg
↑
VO2max
mL/kg/min
35–55 mL/kg/min (trained adults)

What
affects it.

amino-acid
L-Citrulline

Raises blood arginine and nitric oxide more efficiently than arginine itself.

established$
amino-acid
L-Arginine

NO precursor. Poor oral bioavailability — citrulline is usually better.

supported$
amino-acid
Taurine

Supports cardiac function, bile acid conjugation, and neurotransmission.

supported$
mushroom
Cordyceps

Studied for exercise performance and oxygen utilization. Human data mixed.

supported$$

Contributes to these goals.

ALL GOALS →
🏃
Endurance

Sustained aerobic capacity — VO2max, time to exhaustion, and lactate threshold.

🧠
Cognition

Overall brain function — attention, processing speed, mental clarity.