Leydig Cell Function

Leydig cells are the testosterone factories in the testes.

Evidence note: Zinc and vitamin D support Leydig cell function, but only in deficient individuals.

EVIDENCE

supported

INGREDIENTS

BIOMARKERS

What it
changes.

Activating this pathway affects the following measurable biomarkers.

Raised LH and testosterone in rodent studies via GnRH signaling. No human testosterone RCT.

Reduces cortisol in multiple RCTs. May improve testosterone and stress resilience.

Contains 4-hydroxyisoleucine, which stimulates insulin release. Studied for testosterone and creatine uptake.

Fulvic acid mineral complex. Possibly effective for testosterone in hypogonadal men [citation:31].

Essential for testosterone synthesis. Supplementation helps only if deficient.

Hormone-like vitamin. VDR receptors present in Leydig cells. Supplementation matters mainly in deficiency.